Another aspect of the correlation between TLR3 and cell metabolism was explored by some of us (Matijevic et al.)through a proteomic approach, also in an in vitro HNSCC model: stimulation of TLR3 by its synthetic ligand Poly(I:C) resulted in a differential expression of 15 proteins, of which 10 were involved in protein metabolic processes [30]. Here, TLR3 is linked to head and neck squamous cell carcinoma.