Next, we explored the impact of SORBS1 on breast cancer malignancy and metastasis in vivo using a mouse model in which MDA-MB-231 Control and MDA-MB-231 shSORBS1 (shSORBS1-1 and shSORBS1-2) cell lines were implanted by intravenous via the tail. This evidence concerns the gene SORBS1 and breast cancer.