The average FilGAP score was significantly higher in the peripheral lesions as compared to the core lesions within tumor tissues, in contrast to significantly higher FLNa, integrin β2, cytoplasmic ECT2, and cytoplasmic Rac1 scores, as well as plasma membrane/perinuclear Rac1 immunopositivity, and nuclear ECT2 and Ki‐67 LIs in the latter (Fig. 5B and Table S2). This evidence concerns the gene RAC1 and neoplasm.