Four compounds are FN, i.e., a DA1/α1 agonist (232) that induced pancreatic acinar cell adenoma, an imidazole PDE inhibitor (216) that was associated with adrenal pheochromocytomas, a quinolone vasodilator (225), and a renin inhibitor (198) that was associated with colon adenoma and carcinoma. The gene discussed is REN; the disease is adrenal gland pheochromocytoma.