VDR is expressed in all segments of the small and large intestine and active 1,25(OH)2D3 calcium absorption has been reported in the distal as well as the proximal intestine.4 Rickets and osteomalacia are prevented when VDR null mice are fed a diet high in calcium and lactose, indicating that 1,25(OH)2D3 and VDR have a critical role in bone mineralization by regulating intestinal calcium absorption.23,24 1,25(OH)2D3 has been reported to regulate every step of the intestinal transcellular calcium transport process. Here, VDR is linked to osteomalacia.