The dynamic effect of rs7632505 on CHD may be explained by the inhibitory effect of SEMA5B on angiogenesis which is related to aging process (Lähteenvuo and Rosenzweig, 2012) and is purported to be involved in atherosclerosis and other CVDs (Khurana et al., 2005; Deveza et al., 2012). Here, SEMA5B is linked to coronary artery disorder.