Interestingly, inhibition of AChE fails to modulate streptozotozin (STZ)-induced hyperglycemia in IFNγ-deficient (IFNγ−/−) mice, demonstrating the crucial role played by IFNγ in ACh-mediated inhibition of the autoimmune response against islet β cells. The gene discussed is IFNG; the disease is Hyperglycemia.