A nonsense mutation in the exon 9 of TNNT1 gene at codon Ser108 was found in a Hispanic patient in New York City with clinical and histological features were very much like that of ANM, including severe respiratory muscle weakness, type I fiber atrophy and compensatory hypertrophy of type II fibers (Marra et al., 2015). The gene discussed is TNNT1; the disease is nemaline myopathy 5.