Although, the slow TnT deficient slow fibers had active regeneration and hypertrophic growth of type II fast fibers, the muscles showed significantly decreased fatigue resistance (Feng et al., 2009; Wei et al., 2014), consistent with the pathophysiological phenotype of posture muscle weakness and respiratory muscle failure in ANM patients (Johnston et al., 2000). This evidence concerns the gene TNNT1 and nemaline myopathy 5.