progression of mild hyperglycaemia into frank Type I diabetic condition, spontaneous recovery of animals, poor resemblance of the model with human Type II diabetes etc. STZ may be more suitable for developing a rodent model resembling human Type I diabetes, screening newer formulations of insulin, beta cell transplantation studies, and for treatments that may prevent beta cell death (King, 2012). Here, INS is linked to type 1 diabetes mellitus.