CHCHD10 and amyotrophic lateral sclerosis: One example is the recent discovery of the mitochondrial protein CHCHD10 as being implicated in ALS which for the first time proves a direct impact of mitochondria in the pathogenesis of the disease, a result obtained by exome sequencing in several families affected by ALS (e.g., Bannwarth et al., 2014; Müller et al., 2014; Kurzwelly et al., 2015).