Although Fernández-Santiago et al. (2011) as well as Chen et al. (2012) could not confirm an association of variants in ITPR2 with ALS in a German and a Chinese cohort by SNP genotyping, we speculate that variation in the ITPR2 gene could act as a modulating factor in ALS. Here, ITPR2 is linked to amyotrophic lateral sclerosis.