MYH6 and hypoplastic left heart syndrome: Although MYH6 variants have been previously associated with cardiac phenotypes (1, 4, 6, 12, 33, 38), to better understand their role in HLHS we have employed a multifaceted approach including a case-control association study, transcriptome analysis of patient cardiac tissue, clinical outcomes, and the use of patient-specific induced pluripotent stem cells (iPSCs) to model HLHS disease in vitro.