Recently, a series of studies have enlightened that MIF governed angiogenesis, [12] epithelial-mesenchymal transition (EMT), [13] hypoxia [14] and cell cycle [12] in many kinds of human cancers including HNSCC, and indicated that MIF might be a potential driver and biomarker for HNSCC. Here, MIF is linked to head and neck squamous cell carcinoma.