RNAi and small molecule targeting of Enox1 were shown to inhibit migration of human and mouse endothelial cells and the ability of these cells to form tubule-like structures in matrigel, as well as to suppress neo-angiogenesis driven by growth of Lewis Lung Carcinoma tumor cells in a dorsal skin fold vascular window chamber [8]. This evidence concerns the gene ENOX1 and neoplasm.