As such, we believe that these findings are of potential clinical importance, because they imply that DR5-targeting therapeutic approaches should be applied in a personalized manner mostly to patients with TNBC tumours that express EPHB6 and also suggest that simultaneous administration of EPHB6 and DR5 agonists is likely to assure more effective killing of TNBC cells. This evidence concerns the gene EPHB6 and neoplasm.