VEGFA and age-related macular degeneration: The NLRP3 inflammasome in RPE cells can be activated by various factors and conditions that are suggested to be implicated in the pathogenesis of AMD such as complement factors, Alu RNA accumulation, lipofuscin-mediated photooxidative damage, peroxidized lipids, lysosomal destabilization, and overexpression of vascular endothelial growth factor (VEGF) [7–15].