Various lines of evidence indicate that the NLRP3 inflammasome is expressed in the RPE of eyes affected by geographic atrophy or neovascular AMD [7], that NLRP3 inflammasome activation in RPE cells is implicated in mediating RPE cell degeneration in geographic atrophy [8, 9], and that NLRP3 inflammasome activation in the RPE may promote neovascular AMD pathologies like RPE barrier breakdown and choroidal neovascularization [10]. This evidence concerns the gene NLRP3 and atrophic macular degeneration.