There were no statistically significant differences in genotype (P = 0.97) and allele (P = 0.84) frequencies for -295 T/C IL-16 promoter gene polymorphism in patients with psoriasis and control subjects as well as in subgroups of early-onset and late-onset psoriasis (P = 0.84) and mild vs. moderate to severe psoriasis (P = 0.73). This evidence concerns the gene IL16 and psoriasis.