Several additional genes also had PCCs with BRCA1 that differed significantly across tumor types, including AKT1, which encodes a multifunctional serine-threonine protein kinase; XRCC1, a DNA repair gene; and RBBP7, CDS1, and SMARCC2. All of the genes mentioned exhibited decreased expression correlations with BRCA1 in HGSOC (Fig 4, Table 1), suggesting disrupted function of the BRCA1 protein. This evidence concerns the gene RBBP7 and neoplasm.