BRCA1 and neoplasm: Several additional genes also had PCCs with BRCA1 that differed significantly across tumor types, including AKT1, which encodes a multifunctional serine-threonine protein kinase; XRCC1, a DNA repair gene; and RBBP7, CDS1, and SMARCC2. All of the genes mentioned exhibited decreased expression correlations with BRCA1 in HGSOC (Fig 4, Table 1), suggesting disrupted function of the BRCA1 protein.