Reestablishment of good glycemic control, soon after induction of diabetes, however, protects retinal mitochondrial homeostasis and the progression of diabetic retinopathy.12,16,45 Here, we demonstrate that Dnmt and Tet also remain normal, with no change in mtDNA and nDNA (MMP-9) methylation. This evidence concerns the gene DNMT1 and diabetic retinopathy.