DNMT1 and diabetes mellitus: Reinstitution of 3 months of good control after 3 months of poor control, however, did not reverse diabetes-induced increase in retinal Dnmt1 transcriptional activation, and the D-loop region remained hypermethylated with 3-fold increase in 5mC levels and 2-fold increase in Dnmt1 binding; the values were similar to those obtained from the rats in continuous poor control for the entire duration.