Neutrophils are also able to produce other angiogenic factors such as prokinecitin-2 (PK2), also known as Bv8, that appears to play an important role not only in tumor angiogenesis, but also in tumor refractoriness to anti-VEGF treatments.51, 52 Whether low pH plus fever-range hyperthermia might also be able to modulate neutrophil production of PK2/Bv8 remains to be determined. This evidence concerns the gene VEGFA and neoplasm.