To evaluate whether P53 pathway activation is a specific feature of ZIKV-infected neural cells, rather than a nonspecific consequence of viral burden and highly deregulated transcriptome, we analyzed by GSEA the overlap between P53-related sets and genes upregulated in hNPCs after infection with the unrelated microcephaly virus CMV (Luo et al.,41 GEO accession number GSE19345). This evidence concerns the gene TP53 and infection.