To explore more, in general, the extent of P53 pathway activation in ZIKV-infected neural progenitors and in the analyzed microcephaly models, we resorted to GSEA, a powerful analytical method for interpreting gene expression data that focuses on specific gene sets obtained in different and heterogeneous studies.40 In particular, we concentrated our analysis on 50 gene expression signatures related to P53 function and evaluated their overlap with the lists of upregulated in the ZIKV, CitK, Magoh and Elp3 data sets. This evidence concerns the gene ELP3 and microcephaly.