CDH1 and neoplasm: We further tested the effect of EHF on the process of epithelial–mesenchymal transition (EMT), which is one of the critical steps during tumor metastasis including gastric cancer.30 As shown in Figure 6a, knocking down EHF expression in AGS, BGC823 and SGC7901 cells increased E-cadherin expression, and decreased Vimentin expression.