EHF and cancer: It has been well documented that genomic amplification is one of the major causes of oncogene overexpression in human cancers.28, 35 To identify the mechanisms that may contribute to EHF overexpression in gastric cancers, we examined EHF copy number and its mRNA/protein expression in gastric cancers, and demonstrated a significantly positive relationship between them, suggesting that EHF amplification is one of the major mechanisms of EHF overexpression in gastric cancers.