This is supported by previous studies that MMPs genes are key targets of ETS proteins and Ets-mediated induction of these genes contributes to the invasive and angiogenic phenotypes of malignant cells, such as PEA3, ETS1, and ETS2.37, 38 These findings further suggest that EHF may be a potential oncogene in gastric cancer cells. The gene discussed is ETS1; the disease is gastric cancer.