AKT1 and gastric cancer: Increasing evidences have demonstrated that overexpression of HER family members leads to the activation of downstream pathways including the MAPK/Erk and PI3K/Akt pathways.33 As expected, EHF knockdown significantly inhibited the activities of both pathways in gastric cancer cells, characterized by reduced phosphorylation of Erk (p-Erk) and Akt (p-Akt) (Figure 7d).