The HER family includes four members: EGFR/HER1, HER2, HER3 and HER4.31 Alterations in HER family play a critical role in the progression and survival of many cancers including gastric cancer.32 In addition, we found the core GGAA/T motif (EBS) in the promoters of EGFR, HER2, HER3 and HER4 by analyzing their promoter sequences using MatInspector online software (http://www.genomatix.de/online_help/help_matinspector/matinspector_help). This evidence concerns the gene ERBB3 and cancer.