After binding to its receptor on the surface of endothelial cells, VEGF promotes the building of new vessels that help to provide the tumor cells with the required amount of O2 and nutrients, thus ensuring their survival.19 This also leads to their dissemination in the body via the newly formed blood vessels rendered permeable by the VEGF signaling.20 Nevertheless, this tumor vascular network can in turn contribute to the formation of hypoxic areas. Here, VEGFA is linked to neoplasm.