TCHP and neoplasm: In vivo, ATG7 extinction in athymic mice by shRNA, also disrupted tumor growth especially when combined with bevacizumab treatment.115 Another hypoxia-activated protein, the tumor suppressor protein PML (promyelocytic leukemia) activates autophagy by binding mTOR, thereby preventing its interaction with RHEB, causing its deactivation and its nuclear accumulation.127, 128