VEGFA and neoplasm: At present, >100 genes have been identified as targets of HIF1.32 When expressed, these genes allow the cells to cope with hypoxia,33 they promote angiogenesis (VEGF)34 and cell survival (insulin-like growth factor-2),35 they boost glucose metabolism (glucose transporter-1,3—GLUT1,3)36 and facilitate tumor invasion (matrix metalloproteinases—MMPs).37