Indeed, autophagy can positively or negatively regulate both GBM invasion and resistance to therapy, the two hallmarks of GBM aggressiveness.85 Concerning invasion and cell motility, whereas Catalano et al.86 reported an impairment of migration and invasion of GBM cells after autophagy induction, Palumbo et al.87 noticed this impairment after autophagy inhibition, especially when EGFR was coinhibited, thus highlighting the importance of growth factor signaling. Here, EGFR is linked to glioblastoma.