BDNF and obesity due to melanocortin 4 receptor deficiency: Furthermore, a longitudinal reduction in body weight would be expected to reduce the circulating anorexic peptides and this alteration might act as a barrier against long-term diet restriction.[38] Comparable to the results obtained from other anorexic peptides in a previous report from Sumithran et al,[38] our findings also showed that the BDNF AUC index decreased following body-weight reduction in subjects with obesity and metabolic syndrome.