Four additional unrelated families presenting with 20‐nail dystrophy caused by FZD6 mutations have been described (homozygous p.Gly422Asp, homozygous p.Arg509* and compound heterozygous p.Arg96Cys/Glu438Lys), confirming the findings of previous studies.4, 6 To date, five different mutations in FZD6 have been reported in eight families. Here, FZD6 is linked to Nail dystrophy.