Results from those studies indicate that inflammasome components provide protections against tumorigenesis in colitis-associated colon cancer, as mice deficient for inflammasomes, including NLRP3, NLRP12, NLRC4 and caspase-1, have increased tumorigenesis in the AOM/DSS-induced colon cancer animal model24, 25, 26, 27, 28, 29. Here, CASP1 is linked to infectious otitis media.