In agreement with our findings, Fan C et al. recently reported that PBMCs from CHC patients receiving antiviral therapy (both responder and non-responder groups) were cultured with normal medium for 1 day prior to LPS/IFNγ M1 polarization, the polarized M1 macrophages had decreased TNF-α production15. The gene discussed is TNF; the disease is cryohydrocytosis.