CD10 (CALLA; Neprilysin; membrane metalloendopeptidase) is expressed in the tumor microenvironment, where it promotes endothelial cell growth and angiogenesis by mobilizing fibroblast growth factor-2 (FGF-2) and activating AKT1 signaling, a cell proliferation and prosurvival pathway39, 40. This evidence concerns the gene AKT1 and neoplasm.