Because dysregulation of DA has been implicated in psychiatric disorders, including addiction, schizophrenia, and depression (for review, see Hikosaka, 2010), the LHb has gained popularity as a potential therapeutic target for drug addiction and depression-like behavior (Friedman et al., 2010; Sartorius et al., 2010; Christensen et al., 2013; Yadid et al., 2013). Here, LHB is linked to major depressive disorder.