SHANK3 and autism: Post hoc analyses showed a statistically significant decrease, such that there was a >40% reduction in the mean densities of immature DCX+ neurons in the ventral dentate gyrus in both mouse models of autism compared to wild-type mice (WT vs Cntnap2−/−, p = 0.02; WT vs Shank3+/ΔC, p = 0.02).