Our proteomic study supports the possibility that after phosphorylation of GluN2B at Y1472, BEGAIN is transferred to the NMDAR complex of the spinal dorsal horn after peripheral nerve injury, because protein upregulation of BEGAIN in the PSD after SNI was affected by the phosphorylation of GluN2B at Y1472. The gene discussed is GRIN2B; the disease is peripheral nerve injury.