ADAM17 and Coma: As the Bonferroni’s correction applied in the univariate analysis is quite conservative, we chose to include all variables correlated with a P value below 0.05 to include testing of possible false negatives, Hb, lactate, parasitaemia, Blantyre coma score, CIDRα1.4, CIDRα1.1, and ADAM17 in a general multiple linear regression analysis with backwards elimination of covariates (controlled for age and location).