PRKAA1 and diabetes mellitus: Intriguingly, aortae from mice with experimental diabetes exhibit increased basal and IGF-1-stimulated phosphorylation of Akt and AMPKα1 Ser487, with concomitant reduced AMPKα Thr172 phosphorylation [15], and infusion of rats with glucose increased AMPKα1/α2 Ser487/491 phosphorylation [27].