CXCL16 and central nervous system cancer: However, pro-tumorigenic effects of CXCL16 have been reported for several other tumors, e.g. breast cancer [9, 27], lung cancer, and is discussed as a promotor of inflammation-associated cancer in general [28], which is underlined by our own findings, that microglia/macrophages isolated from human glioma samples show high expression levels of CXCL16 themselves [29].