Regarding the biological role of CXCL16 in tumors, contrasting its already mentioned effects in glioma and schwannoma cells [5, 6, 21], high CXCL16 expression correlates with good prognosis and increased levels of tumor-infiltrating lymphocytes in renal cancer [25], while in human rectal cancer a downregulation of CXCL16 has been reported [26]. Here, CXCL16 is linked to rectal cancer.