Other major ribosomopathies include Chromosome 5q- syndrome (5q, OMIM# 153550, acquired RPS14 mutations, macrocytic anemia) [1, 16, 40], Alopecia, Neurological and Endocrinopathy syndrome (ANE, OMIM# 612079, RBM28 mutations) [41], and isolated congenital asplenia (ICA, OMIM# 271400, RPSA mutations), that specifically impairs spleen development [42]. Here, RPS14 is linked to Down syndrome.