Correlation analysis showed that the level of LPS in the plasma of NASH rats was also positively related to the up-regulation of apoptosis, CD68, ROS, P-JNK1/JNK1, IKKβ, GRP78, and CHOP in liver homogenates (Figure 2A-2C). Here, HSPA5 is linked to metabolic dysfunction-associated steatohepatitis.