FHIT and head and neck squamous cell carcinoma: For instance, integration of HPV into ETS2 has been found to result in deletion of exons 7 and 8 at the integration site, resulting in a truncated form of the ETS2 protein in HNSCC [58], and integration of HPV16 into introns of FHIT and LRP1B, resulting in decreased or aberrant protein expression in cervical intraepithelial neoplasia and cervical squamous cell carcinomas [56].