KLF5 and head and neck squamous cell carcinoma: For example, amplification for certain exons of DIAPH2, and deletion of >100 kb segment flanking the same gene have been noted in head and neck cancer-derived UD-SCC-2 cells [70], and amplification and over-expression for complex rearrangement including TPRG1, TP63 and KLF5 have been found in HNSCC [58].