PROM1 and neoplasm: Further investigation revealed that WM130 administration remarkably decreased the levels of EpCAM mRNA and protein in tumor xenografts (Figure 5F, Figure 6C and D), which was accompanied by the increased expression of CYP1A3, G-6-P and ALB. In contrast, DOX increased the expression of EpCAM, CD133 and Oct3/4, but decreased the expression of CYP1A3 and ALB (Figure 5F).