Enhanced processing of major effector caspases (caspase-3, caspase-7, caspase-8 and caspase-9) to their active forms and cleavage of PARP (a target of activated effector caspases) was observed at 48 hours following treatment of the BRAF V600E mutant (A375) human melanoma cell line with ixazomib. This evidence concerns the gene CASP8 and melanoma.