We evidenced herein that Slc7a2–/–mice exhibit less colonic inflammation than WT animals after C. rodentium infection, whereas our previous work showed that Slc7a2–/–mice have worsened colitis when treated with DSS when compared to WT mice [10]; this suggests that different mechanisms orchestrate A/E bacteria-induced mucosal inflammation and experimental colitis initiated by a chemical that destroys the surface of the epithelium. The gene discussed is SLC7A2; the disease is colitis.