Our data suggest that NK cell-mediated IL-6 production by CD11c+ cells is responsible for driving hyperinflammation and increased mortality in T2DM mice infected with Mtb. The mechanism that underlies NK cell hyperactivation in T2DM mice remains unknown, but NK cell activation was recently reported to be an upstream event in T2DM pathogenesis [38]. The gene discussed is IL6; the disease is type 2 diabetes mellitus.