These may also be obstacles to the application of C1-INH in further indications, although clinical studies showed beneficial effects of C1-INH also in other disease states like sepsis, gram-negative endotoxic shock, vascular leak syndrome, transplant rejection, ischemia-reperfusion injury, myocardial infarction, and emergency coronary artery bypass surgery [24,25]. Here, SERPING1 is linked to myocardial infarction.