The physiological importance of C1-INH is reflected in its association with various diseases including hereditary and acquired angioedema (HAE, AAE) with potentially life-threatening attacks of subcutaneous and submucosal edemas [11], and age-related macular degeneration (AMD) being the leading cause of blindness in the elderly in developed countries [12]. This evidence concerns the gene SERPING1 and hereditary angioedema.