CD226 and neoplasm: As complete abrogation of tumor cell killing was not achieved by combined blocking of DNAM-1 and NKG2D on activated PBNK and UCB-NK, other NK killing mechanisms such as NKp44/NKp44L, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and FAS (Fas ligand interactions) also might contribute to the observed target cell lysis [46, 47].