To investigate the involvement of activating receptors in mediating the cytotoxic activity of PBNK and UCB-NK, the expression of the two major NK-activating receptors DNAM-1 and NKG2D on the NK cells described to be involved in the recognition of cervical cancer cells, and their respective ligands, i.e., PVR and MICA/B, ULBPs, on the tested cervical cancer cell lines, were assessed. The gene discussed is KLRK1; the disease is cervical cancer.