BRCA1 and cancer: For example, breast cancer 1 (BRCA1)/breast cancer 2 (BRCA2)-containing complex subunit 3 (BRCC3) deubiquitinates NLRP3, and pharmaceutical inhibition of DUBs restricts inflammasome activation [79,112,113], whereas E3 ubiquitin ligases LUBAC and TRIM33 promote inflammasome assembly [114,115].