Interestingly, however, the sensitivity of the tumor cells to T-cell-derived IFNs was dramatically decreased, evidenced by reduced sensitivity to the anti-proliferative effects of IFNs, decreased signal transducer and activator of transcription 1 (STAT1) phosphorylation (an important transcription factor, phosphorylated by JAK1 and 2), and reduced upregulation of major histocompatibility complex (MHC) class I and PD-L1 in response to IFNs. The gene discussed is STAT1; the disease is neoplasm.