Additionally, the antagonism of A2A an A2B receptors inhibits metastatic progression to lung in a murine model of breast cancer and is dependent on TCD8+IFN-γ+ activated T-cells, indicating that Ado signaling through these receptors also plays a role in the inhibition of effector T-cell activation [53]. The gene discussed is IGKV2D-29; the disease is breast cancer.