Considering that the CD39 and CD73 overexpression in tumors has been associated with a worse prognosis as well as to chemotherapy resistance in patients with several malignances [58], our results contribute in elucidate that the overexpression of CD39 and CD73 on CeCa-MSCs may support the immunosuppressive tumor microenvironment to inhibit the function of the antitumoral effector cells, such as CTLs. The gene discussed is ENTPD1; the disease is neoplasm.