NGF and cancer: In the present study, we demonstrated for the first time that the water extract of Lithospermi radix, which has been used as a traditional medicine to treat diverse diseases including acute hepatitis, cancer, and wound healing [30], can reduce the neurotoxicity of oxaliplatin in an NGF-PC12 in vitro model, and it can attenuate the oxaliplatin-induced nociceptive hypersensitivity in an animal model.