This strategy would also likely bypass any need for antibody‐dependent classical pathway initiation due to the potent complement initiation properties of scFv‐properdin.89 Many bacteria other than Neisseria species including Borrelia burgdorferi,211Yersinia enterocolitica,212 and Streptococcus pyogenes213 bind Factor H (reviewed in 16) to protect themselves from the alternative pathway, therefore scFv‐properdin targeted against Factor H‐binding proteins could be an efficient strategy for treating infections resulting from a diverse array of pathogens. This evidence concerns the gene CFP and infection.