However, this action was fully abolished in liver cancer stem cell lines transfected with pCMV6-A-GFP-HULC plus pCMV6-A-GFP-MALAT1 plus pFGP-V-RS—TRF2 or pGFP-V-RS-GFP-HULC plus pGFP-V-RS –MALAT1 plus pcDNA-CREPT (9.7days, 9.5 days vs 10.2 days, respectively, t-test, P < 0.01) (Fig. 8f). Here, TERF2 is linked to liver cancer.