Pathological picture (HE stain) of xenograft tumor showed that tumor tissue possessed more poor-differentiation cells and less moderately or well-differentiation cells in HULC and/or MALAT1 overexpression group than that of control group, suggesting that HULC and/or MALAT1 overexpression enhanced the xenografts tumor malignant grade (Fig. 3cupper). The gene discussed is MALAT1; the disease is neoplasm.