However, this action of MALAT1 combined with HULC was abrogated in liver cancer stem cell lines transfected with pCMV6-A-GFP-HULC plus pCMV6-A-GFP-MALAT1 plus pFGP-V-RS-TRF2 or pGFP-V-RS-GFP-HULC plus pGFP-V-RS –MALAT1 plus pcDNA-CREPT (0.69 gram, 0.72 gram vs 0.75 gram, respectively, t-test, P < 0.01) (Fig. 8d,e). The gene discussed is RPRD1B; the disease is liver cancer.