Cell growth assay results showed that MALAT1 combined with HULC promotes liver cancer stem cells proliferation in vitro. However, this action was fully abrogated in liver cancer stem cell lines transfected with pCMV6-A-GFP-HULC plus pCMV6-A-GFP-MALAT1 plus pFGP-V-RS—TRF2 or pGFP-V-RS-GFP-HULC plus pGFP-V-RS –MALAT1 plus pcDNA-CREPT (Fig. 8b). Here, RPRD1B is linked to liver cancer.