Taken together, our study uncovers a novel pathway by which the TGFβ-activating integrin αvβ8 is expressed in the human intestine on DC subsets, which is upregulated in patients with CD, and which may be an attractive therapeutic target to drive TGFβ-mediated suppression of inflammation in the intestine. The gene discussed is TGFB1; the disease is Cowden disease.