In this regard, cytogenetic abnormalities highlight the putative involvement of the loci from Xq12 to Xq21 and Xp22 in autism pathogenesis [10,11], as well as associations with structural variants that have been reported for some X-chromosomal genes, such as NLGN4X and MECP2 genes [12,13,14,15]. The gene discussed is NLGN4X; the disease is autism.